Long-term stress can cause depression and cause social problems. A new French study found the neurobiological mechanism behind this phenomenon through animal experiments, which helps to develop drugs for the treatment of stress-related mental diseases. The French National Research Center issued a communiqué on the 18th that said that a group of experimental rats and more powerful, Putting together more aggressive peers, they will show anxiety after being repeatedly attacked for more than ten days, and then strongly dislike socializing, and are unwilling to contact newly encountered peers. These phenomena are considered a sign of depression.
However, if the experimental mice are modified to lack a substance called glucocorticoid receptors in their nervous system, they still have anxiety after going through the same experiment, but they do not hate social interactions and are still willing to contact with the same kind . These experimental rats are considered to have stronger antidepressant ability. Further research shows that the reason why these experimental mice can resist depression is that due to the lack of glucocorticoid receptors in the nervous system, the release of dopamine will be reduced accordingly. Dopamine is a neurotransmitter responsible for transmitting information. In this experiment, it is reduced. Can avoid a series of depression reactions.
For experimental rats that have shown symptoms of depression, if they directly interfere with certain neurons that release dopamine, they can make them willing to contact with the same kind again. The researchers believe that these findings help to develop drugs to treat mental illness caused by stress.
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