Synthesis of 2- [4-bis- (4-fluorophenyl) methyl] piperazine acetylhydrazone compound under microwave irradiation.pdf

Under microwave irradiation, using acetone as the solvent, 1- [di- (4-fluorobenzene) methyl] piperazine reacts with ethyl chloroacetate to give 2- [di- (4-fluorobenzene) methyl] piperazineacetic acid Ethyl ester (1), 1 is reacted with hydrazine hydrate under microwave radiation to obtain 2- [di- (4-fluorophenyl) methyl] piperazine acetohydrazine (2), further under microwave radiation from 2- [di -(4-fluorophenyl) methyl] piperazine acetohydrazide (2) reacts with substituted aromatic aldehydes to prepare target compounds 3a ~ 3f. The synthesized six target compounds were analyzed by melting point determination and mass spectrometry, infrared spectroscopy, nuclear magnetic resonance hydrogen spectroscopy , Elemental analysis to confirm its structure.

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