With the improvement of the pharmaceutical market in China and the classified management of prescription drugs and over-the-counter drugs, higher requirements are placed on pharmaceutical packaging. Today, domestic packaging companies are irrespective of their size, production technology, management level, product variety and quality. Significant progress has been made, new products and new technologies have been widely used, and backward products and technologies are gradually being eliminated.
The medicinal glass has already been widely used in the field of pharmaceutical packaging, and is still in the rising stage of development. Manufacturers should pay more attention to the upgrading of pharmaceutical glass itself, product upgrades, and integration with international standards.
Due to the effects of temperature, humidity, air, light, microorganisms, and insects, the stability of the drug may deteriorate. In this case, the advantages of the glass bottle are revealed because of its superior protection properties and good chemical stability. At the same time, the glass is not affected by the atmosphere and is not decomposed by solid or liquid substances of different chemical compositions. Characteristics, and by changing the chemical composition of the glass can adjust the chemical properties of glass and radiation resistance, therefore, glass has become the best drug, the most commonly used packaging containers. It also increases the market value and prospect of medicinal glass. In addition, according to the aesthetic principle and non-pollution principle of drug packaging material selection, medicinal glass is transparent and beautiful, and it is inexpensive and recyclable. Unlike post-processing of PVC materials, it is very difficult , brings extremely serious environmental problems.
Nowadays, due to its unparalleled characteristics and advantages, medical glass has been widely used in various packaging fields such as injections, powder injections, biological medicines, blood products, lyophilizers, tablets, and oral liquids in China. .
According to the different uses of products can be roughly divided into the following categories:
Infusion packaging: The domestic infusion packaging is mainly based on glass infusion bottles. Plastic infusion containers have gradually grown, but high-quality, lightweight Type II infusion bottles still have certain competitive advantages. The glass infusion bottle has the characteristics of smooth, transparent, easy to sterilize, erosion resistance, high temperature resistance, good sealing performance, and is still the preferred packaging for common infusion liquids.
Oral liquid packaging: Oral liquid preparations are mostly health products, most of which are packed in pharmaceutical glass, mainly controlled white and brown oral liquid bottles and molded brown glass medicine bottles.
Freeze-dried packaging: The lyophilized packaging contains the control bottles and molded bottles. Previously, there are ampoules and they are basically eliminated.
Tablets and Capsules Packaging: In recent years, tablets and capsules have been continuously replaced by plastic bottles, aluminum foils, etc. However, high-quality lightweight and light-resistant yellow or white glass bottles still have irreplaceable advantages and developments. space.
Powder injection packaging: powder injection is one of the five major pharmaceutical preparations in China, with various types of antibiotics as the main products, and its packaging is mainly molded injection bottle and controlled injection bottle. At present, in domestic powder injection packaging, molding injection bottles account for 70% to 80% and control injection bottles account for 20%-30%. The former is characterized by stable dimensions and high strength; the latter is characterized by light weight and good appearance transparency. At present, the controlled injection bottle has gradually increased at home and abroad.
Water injection packaging: The main form of water injection packaging is ampoule. There are two types of curved neck ampoules produced domestically: one is that there is a nick on the neck of the ampule, and there is a color point mark on the top of the nick; the other is that the neck of the ampule has a ring of low-melting glass color ring, because of the color ring and Ampoule glass itself has different coefficients of expansion, which can cause local stress and break easily.
China is currently in a period of rapid economic and technological development. Drug exports are increasing. Foreign businessmen are paying more and more attention to the quality of glass used in packaging medicines. Although in recent years, pharmaceutical glass production in China has made great progress, it is similar in the world. Compared with products, there is still a big gap in the production of pharmaceutical glass in China.
Mainly manifested in: the level of product standards, physical quality is poor, the structure is irrational, product quality and low added value, so that the contribution of pharmaceutical glass to the pharmaceutical economy is significantly lower than developed countries. Therefore, medicinal glass production should be brought into line with the international level as soon as possible from the following aspects. At the standard level, we must actively adopt international standards, comprehensively improve the quality level of products, and establish and perfect the standardization system of pharmaceutical glass in China as soon as possible. In terms of type, the international standard ISO12775-1997 clearly states that there are mainly three types of medicinal glass: 3.3 borosilicate glass, international neutral glass, and soda-lime glass. Due to the limitation of our country's technological level, we have not been able to produce international neutral glass with strong water resistance, acid resistance, and alkali resistance on a large scale. We should gradually transition in the future to focus on the development of international neutral glass. In terms of material properties, the international neutral glass and 3.3 borosilicate glass particles can reach a level of water resistance. Although most of the low borosilicate glass particles in China have a water resistance rating of 1 and some of them have a rating of 2, the amount of alkaline precipitation from microscopic views is several times larger than that of international neutral glass. In terms of the limit of harmful substances, there are regulations on the amount of As, Sb, Pb, and Cd in glass that are released internationally. As the medical glass with the highest requirements for safety and health, China should limit the amount of harmful elements that will be released to ensure the safety of people's medication. The test method should be quantitatively and quantitatively developed from the original qualitative, semi-quantitative and quantitative. Such as the internal surface water resistance, in the past with the methyl red acidic solution discoloration method, now using the total amount of alkali titration method, the international still have to Na, K, Ca, respectively, quantitative determination.
As a main branch of pharmaceutical packaging industry, medicinal glass will continue to be an important pharmaceutical packaging material in the future and even a long time. We are looking forward to the pharmaceutical glass bottle market in China continuously strengthening its own development, actively developing its own potential, and sharing a slice of the world pharmaceutical packaging stage in the near future!
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