The utility model discloses a novel bottle mouth sealing anti-counterfeiting device, which comprises an inner body and an outer body. The inner body and the outer body are mutually nested and are placed in a bottle mouth; wherein, the inner body is a cylinder structure and the interior is provided with a continuous wine The liquid passage and the liquid passage are provided with a movable piston and a cup body. The device has a good sealing effect, effectively preventing the remaining liquor in the bottle from deteriorating due to the volatilization of alcohol; the entire device is closely combined with the bottle mouth to prevent manual disassembly and forgery; and adulteration such as syringe injection is prevented. The device is particularly suitable for the sealing and anti-counterfeiting of bottled liquor, beverages, etc., and is particularly effective for sealing and anti-counterfeiting protection of expensive liquors.